I've mapped my wacom so that I only use the top left corner of the tablet. I'm right handed and this layout gives me something to rest my wrist on when working in the bottom of the screen - previously my wrist was on the desk when I was working near th bottom.
Oh and that is with the small tablet. With a medium tablet I guess you would have a bigger "resting pad'
Oh and that is with the small tablet. With a medium tablet I guess you would have a bigger "resting pad'