No... presets are applied equally to the entire image...
There are other tools to select/adjust blemishes, skin tones, eyes etc...
An example might be in order...
You have a color image of a less than beautiful woman...
You might select a preset that applies a Sepia tone to the entire image...
after that, using the individual brush/selection tools, gradients, you could them remove the blemishes, and lighten specific areas of the image making an average woman look better...
If you do a lot of portraiture and touchup of people... there are standalone/and add-in programs that refine and speed up the editing process using face-recognition metrics to make those adjustments...