My only beef with it is that it's about 1/2" too shallow to hold my 16-35mm and 3/4-1" too shallow to hold my Sigma 105mm without the back cap poking out above the side padding. It's still okay since the compartment cover is also padded, but I'd be happier if it was just a little bit deeper. It holds a body with the Sigma 150-500mm attached, which is sweet, but if I also want the 70-200mm f4 then I need to make hard decisions on what other lenses to take (i.e. 2 zooms or 3 primes?). Not complaining, mind you. If I need two lenses with that kind of reach then I'm probably not going to be looking to do landscapes. I'm also bummed that it won't hold my MeFoto Daytripper tripod standing up, but I can carry the full sized one on the outside.
In other words, it won't hold everything, but it'll hold enough for a planned trip.