Well to start, whatever lens you use will perform at its best closed down a couple of stops.
then use 200 ISO for detail. The most common cause of unsharp pics is simply shutter speed not being fast enough.
a genral rule of thumb is to use a shutter speed no slower than the focal lengh you are using. IE... 50mm = 60th sec
except remember on apsc.. that 50 = 75mm so 125th would be mor apropiate.
Have fun