This is my biggest complaint with LR is you really can't use Nik with it. So for now I am using LR for cataloging only and then switching to Bridge and then ACR and then to PS so Nik works like I want it to.
But great tips on Nik though. I had not heard (or read) about the order of use with sharpening and Define. Generally use those but not all the time and not in that order. Will have to try that next time I do post processing.
You can use the NIK stuff with LR, and I've kinda developed my own workflow with the NIK tools. When you edit a photo in a NIK plug-in, you just need to always select the "Edit a copy with Lightroom adjustments" option each time you go from LR to one of the NIK tools. Each time you edit the photo in a NIK tool and then click save to return back to LR, it adds the word "edit" to the file name. As long as you always work with the file with the most number of "edit"s in the file name, you're working on the cumulative effects from all previous NIK edits. You then delete the previous copies from the stack as you go. It's not the most elegant or seamless workflow, but it works fine.
NIK's recommended workflow:
"1. If desired, apply Raw Presharpener using Sharpener Pro 3.
2. Apply noise reduction using Dfine 2.
3. Control color and light using Viveza 2.
4. Apply filter enhancements using Color Efex Pro 4.
5. Convert to black and white using Silver Efex Pro 2.
6. Apply output sharpening using Sharpener Pro 3.
Note: Analog Efex Pro 2 can be utilized at any point after Dfine 2. HDR Efex Pro 2 is best used immediately after Dfine 2."
From here:
https://support.google.com/nikcollection/answer/3000890?hl=en
That's the workflow I use, except I do basic edits to white balance/temp, contrast, clarity, vibrance, CA removal, lens profile corrections, straightening, and cropping in LR as the first step, because after you export to any NIK tool, it's no longer a RAW file anymore, it becomes a TIFF. Therefore, if you don't do these basic adjustments in LR as the first step, you can't use LR's lens profile corrections or the "Adobe standard/landscape/ portrait/vivid" picture modes once the image is no longer RAW. On that first LR adjustment step, I drag the sharpening and noise reduction sliders all the way to the left (0), since I'm going to do all sharpening and NR using the NIK tools. I will also add any spot removal in LR somewhere after the Dfine 2 NR step above. If I'm planning to merge multiple bracketed images into an HDR, I will do the first 2 steps above to each image first, along with lens profile corrections, then import the images into Photomatix (I prefer it vs the NIK HDR Efex Pro personally), then continue with step 3.
However, I'm nowhere close to being as skilled as I want to be (and as some of you folks are) with post-processing, and I know the possibilities are endless. I'm always trying to evolve, but this is what I do now.