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Message: <blockquote data-quote="WayneF" data-source="post: 305039" data-attributes="member: 12496">I don't know.  ISO ought not to affect obstructions, however the two exposures are not nearly the same.  Perhaps if they were more nearly the same, it would look more the same?But there is little advantage in trying to reason it out.  It needs not to do that.   It needs cleaning (esp the sensor too) with a Rocket blower brush.  It just squirts air in there, but safe air, not excessive pressure, and no liquid propellents.    Then after than, if still present, then worry more about it.  <img src="data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7" class="smilie smilie--sprite smilie--sprite1" alt=":)" title="Smile    :)" loading="lazy" data-shortname=":)" /></blockquote>