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Message: <blockquote data-quote="J-see" data-source="post: 426568" data-attributes="member: 31330">I don't know anything about microscopy but for macro it depends a bit what you want to shoot.If you shoot subjects where light is of little importance (static subjects or if you use flash) a crop sensor might do better. With a dedicated macro lens the detail the lens will resolve is identical for a FX and DX since they're both at the exact same distance at 1:1 but while the FX might have a better SNR, the DX will have the edge detail-wise. It evidently depends which DX and FX you compare and a 36Mp FX will do better than a 24Mp. Between some the differences might be minimal and you'd need to pixel-peep to see them.The moment light is an issue and you need to up the ISO, FX is the better choice.</blockquote>