That is a good idea to run it through Dfine. I always get so engrossed in one thing that I completely forget about all of the other programs in the collection. I'll definitely have to have more of a play around with it all! Thanks for that Jake.
It's good to have a designated workflow and then omit steps you don't want or need. For me it's...
1. Lightroom for basic adjustments - lens profile correction, cropping and straightening, basic light adjustment (tweak highlights, whites & blacks, apply gradient if needed, etc.)
2. Send to Photoshop, first step is to duplicate the background layer (ctrl-J) to preserve the original
3a. Fix any dust spots, remove "extras" like power lines, tree branches, etc.
3b. Hit ctrl-L and adjust light balance again (I usually hit Auto just to see what it does, hit ctrl-z to undo, and then go from there).
4. Call Dfine 2.0 for noise reduction
5. Do basic lighting tweaks in Viveza 2 (If lighting is a little "weird" I may now call HDR Efex Pro 2 and do some tone mapping.)
6. Apply and other filter programs: Color Efex Pro 4, Perfect Effects 8, Sliver Efex Pro 4, etc.
7. Take another look at noise and possibly call Dfine again. This time I may paint out background noise using a layer mask, varying opacity if applicable.
8. Do final color and light balancing using adjustment layers.
9. Save it back to Lightroom
10. Make color specific adjustments to Hue, Saturation and Luminance, tweak clarity and anything else tweak-worthy.
At this point I may go back to Photoshop and make additional adjustments if I'm not happy with something, otherwise I'll go back, flatten the image and resave (this changes nothing but file size).