My MacBook Pro (15" Retina, 16GB memory, 750GB SSD) is my main computer. I have LR5.6 and Adobe Creative Suite 6 installed in it. This is my 3rd MacBook Pro in 8 years. I also run Windows 7 in the MacBook Pro (under VM Ware) and run the Windows version of LR and CS 6 in it.
When I'm in my office, it's attached to a Dell U2713 Ultrasharp Monitor via the thunderbolt port (the monitor is the last in the daisy-chain - the other 3 devices are a pair of 2 TB LaCie Drives and a Belkin Thunderbolt hub.) fyi, the Dell monitor has a Minidisplay port (as well as a regular display port) but Thunderbolt is plug compatible with MiniDisplay port if the MiniDisplay port device is at the end of the thunderbolt chain!
I do a lot of product photography with this setup - and shoots tether with LR.